Poster Presentation 31st Annual Lorne Proteomics Symposium 2026

p53 Aggregation: Its Mechanics and Potential Contribution to the Development of Alzheimer’s Disease (#41)

David Lynch 1 2 , Madeline Demny 3 4 , Nemil Bhatt 1 2 , Nikita Shchankin 1 2 , Sangho Yun 5 , Arthur Laganowsky 5 , Phanourios Tamamis 3 4 , Rakez Kayed 1 2
  1. University of Texas Medical Branch, Galveston, TEXAS, United States
  2. Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, United States
  3. Chemical Engineering, Texas A&M University, College Station, Texas, United States
  4. Materials Science and Engineering, Texas A&M University, College Station, Texas, United States
  5. Chemistry, Texas A&M University, College Station, Texas, USA
Publish consent withheld
  1. Feroz, W., & Sheikh, A. M. A. (2020). Exploring the multiple roles of guardian of the genome: P53. Egyptian Journal of Medical Human Genetics, 21(1), 49
  2. Farmer, K. M., Ghag, G., Puangmalai, N., Montalbano, M., Bhatt, N., & Kayed, R. (2020). P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease. Acta neuropathologica communications, 8(1), 132.
  3. Chang, J. R., Ghafouri, M., Mukerjee, R., Bagashev, A., Chabrashvili, T., & Sawaya, B. E. (2012). Role of p53 in neurodegenerative diseases. Neurodegenerative Diseases, 9(2), 68-80
  4. Uversky, V. N. (2016). p53 proteoforms and intrinsic disorder: An illustration of the protein structure–function continuum concept. International journal of molecular sciences, 17(11), 1874.