Saturday, 7th February 31st Annual Lorne Proteomics Symposium 2026

Proteomics in Focus: From Molecular Detail to Organ Dynamics

Featuring A/Prof. Nichollas E. Scott and Prof. David W. Greening

A/Prof. Nichollas Scott will share how energy-resolved MS on the Orbitrap Astral™ Zoom Mass Spectrometer distinguishes subtle isomeric protein and glycan alterations through unique fragmentation patterns—revealing molecular details standard proteomics often cannot detect.

Prof. David Greening will present discovery-based methods transitioned to large-scale differential expression analysis to define spatiotemporal protein dynamics in the heart. Here, we explore strategies to capture the subcellular architecture of the heart, advancing the study of the nuclear cardiac proteome, lipid-proteomics data integration, and a blueprint of molecular hallmark features of the cardiac niche.

• Proteomics and Spatial Proteomics Application in Reproductive Cancer - Peter Hoffmann
• Pre-Ribo Mega-SEC enables separation of nucleolar pre-ribosomal particles in human cells  - Harunori Yoshikawa
• Accelerating drug discovery with interactomic technologies - Tess Branon
• Disease-specific tau polymorphs define unique protein interaction networks across proteinopathies - Rakez Kayed

• From Pills to Pathway: Polypharmacy through the Lens of Proteomics & Systems Pharmacology - Kevin Winardi
• The vaginal microbiome as a key contributor to genital mucosal vulnerability to HIV in South African adolescent girls and women - Lindi Masson
• Actionable T Cell Targets in Paediatric Diffuse Midline Glioma: From H3K27M Neoantigen to Dark Antigens - Tima TS Shamekhi
• Repurposing PROTAC-mediated degradation to boost specific antigen presentation for immunotherapeutic synergy - Ilisia Ow
• Sepsis Serum Profiling Identifies a Unique Proteomic Signature Associated with Diastolic Dysfunction - Harley R Robinson

• Proteomic profiling of the macrophage response to micro- and nanoplastic exposure  - Cheng Shen
• Towards proteomics-based prediction of ex vivo platinum sensitivity in ovarian cancer ascitic cellular aggregates - Jack Scanlan
• Phenolic Extracts from Brewing Waste Offer Novel Modulators of Protein Aggregation for Parkinson’s Disease - Blagojce Jovcevski
• Cross-species analysis of SMYD5-mediated RPL40 methylation - Tara M Keogh

• Combining Sensitivity, Selectivity, Speed and Resolution for ​Quantification of Peptide Biomarkers using the Xevo MRT High Resolution Mass Spectrometer​ - Caryn Hepburn
• Proteoform-level identification for comprehensive profiling of proteomes using Integrative Top Down Proteomics  - Luke A Farrell
• Charge Detection Mass Spectrometry Analysis of Thermally Activated Native Protein Complexes - Caryn Hepburn
• Multiomics Data Integration: Transforming big data into comprehensive insights - Khatereh Motamedchaboki
• Optimising Trap Column Design for High-Throughput UHPLC–MS Proteomics  - Greta Briedyte
• Clearance of apoptotic and necroptotic cells drives macrophage reprograming with wound healing potential - Israt Jahan Ripa
• Mechanistic Insights into PTPRK-mediated Hepatic Metabolic Regulation - Amanda Crystal Wei Jin Lee
• Improved Detection of Cross-Linked Peptides with Orbitrap Astral - Han-Chung Lee
• Mass Spectrometry-Based Analysis of IgG Subclonal Variability - Shannon Schutt
• Development of an untargeted spatial proteomics analysis, using matrix-assisted laser desorption/ionisation mass spectrometry imaging, and novel open-source bioinformatics - Samuel T Gould
• Enhanced sensitivity of the Orbitrap Astral Zoom mass spectrometer for deeper proteome coverage in single-cell proteomics applications - Jose Barreto
• The Secret Life of Proteins and Drugs Through the Lens of Proteome Thermal Stability - Atul Bhatnagar
• Engineering a next generation cumate inducible system for precise and tunable gene expression in Burkholderia cenocepacia - Hamza Tahir
• Spatial proteomic profiling of tumour tissue using Deep Visual Proteomics - Sara M Osorio Quinones
• Regulation of protein translation by post-translational modifications in yeast and human - Joshua J Hamey
• High-sensitivity subcellular spatial proteomics of ciliary organelles using the Microscoop and Orbitrap Astral mass spectrometer - Ellen Casavant
• Unlocking the Archived Proteome: Deep spatial analysis of FFPE tissues in minutes - Ellen Casavant
• Molecular Determinants of Lymph Node Metastasis in Endometrial Cancer: A Spatial Proteomics Investigation - Krisha H Chokshi
• Hybrid-DIA and SureQuant for integrated targeted and discovery proteomics on the Orbitrap Astral Zoom mass spectrometer - Maz Ali
• Highly Multiplex Targeted Proteomics Assay in Disease Plasma using Stellar Mass Spectrometer with Adaptive RT - Denise Tran
• A new approach to enhance hypothesis-driven biomarker verification using multiple target monitoring - Hayley Scrivens
• MaSpeQC: An easy-to-use interactive pipeline to assess the performance of LC-MS/MS instrumentation - Ralf B Schittenhelm
• Dynamic organellar mapping of macrophages during dead cell clearance - Dilara C Ozkocak
• Interspecies conservation of post-translational modifications in eukaryotic ribosomes - Thomas Smallbone
• Exploring the forest cobra (Naja melanoleuca) venom using an integrated top-down mass spectrometry-based approach   - C. Ruth Wang
• Affinity-directed proximity labelling to determine the cellular footprint of human endogenous retroviruses.  - Aquilina Kazzi
• An End-to-End Workflow for Sensitive Single Cell Proteomics at 95 SPD - Mark Larance
• Skyline-Driven Targeted Data Extraction in diagonal-PASEF Workflows - Steve Wilson
• Spatial and low input proteomics at scale using the timsUltra AIP and standard gradients on the Evosep Eno - Adam Rainczuk
• Enhancing Biological Discovery with High-Sensitivity Ion Activation on timsOmni: A Flexible Analytical Platform - Steve Wilson
• Tumor microenvironmental interactomics reveals novel neuroblastoma therapeutic strategy by co-targeting of secreted factors that dampen immune response. - Wei Wu
• Multi-dimensional High-Throughput Molecular Glue Screening via Gas Phase Affinity Selection Native Mass Spectrometry and Cryo-EM Analysis - Daniel Hermanson
• timsMetabo for Proteomics: Bridging Omics for Deeper Biological Discovery - Jonathan Moss
• Motif-based clustering of phosphosites reveals co-regulatory relationships in Saccharomyces cerevisiae - Heather McDonald-Haynes
• Comparative Nutritional Analysis of Kiwano (Cucumis metuliferus) Fruit Parts and Leaves Using Mass Spectrometry - Adekunle David Micah
• Characterization of an FFPE Amyloidosis TMA By Multiplexed and MALDI Imaging Based Spatial Proteomics - Larissa Meyer
• TP53 Loss and Mutation Reshape the Immunopeptidome and Antigen Processing in Acute Myeloid Leukemia - Farnaz Fahimi
• Defining the spatial immunopeptidome of mouse spleen - Seyed Mohammad SJ Javadzadeh
• Repurposing metformin as a chemopreventative in colorectal cancer: phosphoproteomics of cell signalling. - Vo Van Anh Pham
• Characterization of α2,8-linked sialic acids on red blood cells using STaBL methodology - Ellen S Hayhoe
• High sensitivity identification of N-linked glycopeptides in human plasma using alternative fragmentation - Cindy Liang
• Label-free quantitative proteomics with high precision and accuracy, driven by ultra-high-sensitivity MS/MS - Jeremy JP Potriquet
• Quantitative proteomics using high-sensitivity data-independent acquisition on a new Q-TOF platform - Jeremy JP Potriquet
• Cleaning up the liver: Dietary creatine regulates hepatic survival adaptations in type 2 diabetes - Jackie Zhou
• Combining laser microdissection with LC-MS/MS spatial proteomics using mouse FFPE tissue - Yuen Tung Ngai
• Optimising Sulfo-SDA Crosslinking Mass Spectrometry on Orbitrap Eclipse and Astral Platforms for Protein Interactomics - Steve Binos
• 500-Samples-Per-Day Plasma Proteomics Powered by Proteonano HT Assay - Hao Wu
• A multi-omics analysis of dendritic cell responses to type I and Type III interferons. - Nicole Amiet
• Examining plasma polymer-coated Indium tin oxide (ITO) slides to enhance analyte detection in MALDI mass spectrometry imaging (MSI). - Manuela Klingler-Hoffmann
• Si-Trap: Simultaneous, detergent-free proteomic, metabolomic and lipidomics sample preparation  - John P Wilson
• nanoPhos enables ultra-sensitive and cell-type resolved spatial phosphoproteomics - Denys Oliinyk
• BAM-Boozled: Pyocin L1 and Darobactin Disrupt Outer Membrane Protein Assembly in Pseudomonas aeruginosa - Imogen Samuels
• Application of structural modeling-assisted cross-linking mass spectrometry to reveal DENV NS2B interaction when bound to NS3 - Radoslaw Sobota
• Crosslinking-MS of E3 Ligases TOPORS and RNF4 with Photoreactive E2~Ub/SUMO Probes - Sarah Chandler
• Cross-species analysis of SMYD5-mediated RPL40 methylation - Tara M Keogh
• Proteomic profiling of the macrophage response to micro- and nanoplastic exposure - Cheng Shen
• Towards proteomics-based prediction of ex vivo platinum sensitivity in ovarian cancer ascitic cellular aggregates - Jack Scanlan
• Phenolic Extracts from Brewing Waste Offer Novel Modulators of Protein Aggregation for Parkinson’s Disease - Blagojce Jovcevski
• Combining Anion Exchange and Size Exclusion Chromatography for Extracellular Vesicle Enrichment from Small Volumes of Human and Mouse Plasma for Quantitative Proteomics - Felicity Dunlop
• Feeding the Fungus: Nitrogen and Time Rewire Protein and Lipid Metabolism in Mortierella alpina - Mike Norman

Next generation of multiomic systems Featuring  - timsTOF & timsOmni

Title: High sensitivity immunopeptidomics on timsTOF platforms

Presenter: Prof. Tony Purcell, Monash University, Melbourne

Title: Powering the Next Era of Precision Mass Spectrometry with timsOmni

Presenter: Guillaume Tremintin, Bruker Scientific LLC, Innovations Technical Specialists Senior Manager

• Influenza A virus infection perturbs host cell glycosylation profiles - Ben L Schulz
• The diversity and evolution of protein N-glycosylation in Metazoa - Fabian Ruperti
• Sialic acid glycofeatures for detection of high-grade serous ovarian carcinoma in serum and ascites - Kristina Mae Bienes
• Dual lipid–proteomics analytical workflow reveals organ-wide sex-dependent subcellular organisation in the mouse heart - Haoyun Fang

• Nanopore proteomics: defining modifications in full-length polypeptides - Hagan Bayley
• Native Mass Spectrometry Analysis of Higher Order Protein Complexes Enabling Drug Discovery - Sally-Ann Poulsen
• Sniper Immunopeptidomics Enables Targeted Detection of Known T-Cell Therapy Antigens from Minimal Clinical Material - Gabriel Goncalves
• Multi-omics discovery of hallmark protein and lipid features of circulating small extracellular vesicles in humans - Alin Rai
• Systematic Proteome-Wide Target Interrogation of PROTAC activity by High-Throughput DIA-MS on the Orbitrap Astral Platform - Ghizal Siddiqui

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