Friday, 6th February 31st Annual Lorne Proteomics Symposium 2026

The ZenoTOF 8600 system: from single cells to diverse proteomics applications.

Speaker: Denys Oliinyk

Organization: Max Planck Institute of Biochemistry (Mann Lab)

• From prevention to treatment: a proteomics-driven approach to transforming fungal disease management - Jennifer Geddes-McAlister
• Metaproteomics for uncovering drug-microbiome interactions - Daniel Figeys
• The Use of Structural Proteomics in the Analysis of Antimicrobial Resistance Mechanisms of Acinetobacter Baumannii - Aiden Brennan
• Proteomic Profiling of Klebsiella pneumoniae Under Infection-Mimicking Conditions Reveals Environment-Specific Adaptations - Breyer Woodland

• Simultaneous Measurement of the Proteome and Lipidome of Individual Cells - Leonard Foster
• Understanding host-microbiome interactions in early type 1 diabetes with stool proteomics - Emma Hamilton-Williams
• Bridging clinical ontologies and proteomics to overcome statistical limitations in rare disease research - Ericka Corazon Itang
• Integrating quantitative proteomics and PISA to identify molecular targets of novel anthelmintic compounds in the model parasitic nematode Haemonchus contortus - Tao Wang

• Constructing region-specific nuclear map of the heart - Seyed Sadegh Eslami
• Spatial proteomics to study immune cells driving inclusion body myositis - Kael Schoffer
• Secretome-Driven Modulation of CD8⁺ T Cell Function in the Pancreatic Tumour Microenvironment - Ragini Bhalla
• Copper intrauterine device (IUD) use associates with metaproteomic signatures of genital inflammation, altered epithelial barrier function, and microbial dysbiosis in South African women   - Nina Radzey
• Proteomic Signatures of Noise Damage: A Comparative Study in Rat Inner Ear and Systemic Fluids - Motahare Khorrami

• Differential Regulation of Cytoplasmic and Secreted Proteins in Staphylococcus aureus Under Host-Mimicking Conditions - Ching-Seng Ang
• Cellular Heterogeneity and Radiation Resistance in Diffuse Midline Glioma: A Single-Cell Perspective. - Dylan H Multari
• Lyophilization prior to homogenisation and extraction increases protein yield and enriches for membrane proteins in proteomic analysis of Gram-negative bacteria - Breyer Woodland
• Data-Independent acquisition for comprehensive immunopeptidome profiling on a modified Orbitrap Astral mass spectrometer - Joanne Ford
• Complementary proteomics approaches for identification of interacting partners and function of the malaria parasite regulatory protein Alba4 - Meghan E Zadow
• Leveraging advanced mass spectrometry technology with Orbitrap Astral Zoom MS for in depth immunopeptidome profiling - Tyren Dodgen
• Proteomics and O-Glycoproteomics – Comprehensive Profiling of Colorectal Cancer Patients in Stages I–IV - Mariusz G. Fleszar
• Defining the antigenic landscape of ewing sarcoma for HLA-dependent T-Cell therapy - Grace Huang
• Enabling reproducible integrative multi-omics analyses using the MultiScholaR R Shiny graphical user interface - C. Ruth Wang
• Vaginal metaproteomic and inflammatory profiles during pregnancy and relationships with birth outcomes - Jenna Wilson
• Cancer Testis Antigens are Potential Targets for Immunotherapy for the Prevention and Treatment of Relapsed and Metastatic Osteosarcoma - Mersedeh Shayan
• Radiation-Induced Proteome and Immunopeptidome Remodeling in H3K27M Diffuse Midline Glioma Cells - Nurfarhanah Syed Sulaiman
• The Proteomic Analyst Suites: A collection of easy-to-use interactive web applications to analyse and visualise proteomic datasets - Haijian Zhang
• Understanding Glycosylation Regulation: Impact of Flippase Modulations on Mediating O-glycan Toxicity Within Burkholderia cenocepacia - Tak To Duncan Ho
• Multi-dimensional Immunopeptidomic Analysis of Tumour, PBMC, and Plasma in Gliolastoma - Erwin Tanuwidjaya
• Proteomic Signatures of Lead Exposure and Adaptation in House Sparrows from Australian Mining Towns - Zeshan Ali
• Investigating The Molecular Interactions of Novel Proteins Driving Treatment Induced Neuroendocrine Prostate Cancer. - Hadeel Doehler
• PromarkerEndo: a blood-based proteomic test for endometriosis - Scott Bringans
• Benchmarking Plasma Proteomics Workflows: Balancing Depth, Reproducibility, and Pre-Analytical Bias on a timsTOF HT Platform - Susanne I Wudy
• PromarkerD performance across diverse populations for early detection of diabetes-related kidney disease - Richard Lipscombe
• Amino acid site preference and allotype-specific variation in glycosylation of class I immunopeptides - Joshua Fehring
• New tools for the antimalarial toolbox: novel proteomic approaches for drug target ID in malaria parasites - Joshua P Morrow
• From Chemistry to Clinic: Improved Cell Surface Proteomics Workflows for Target Discovery in Acute Myeloid Leukaemia (AML) - Vineet Vaibhav
• A Window of Opportunity: Liquid Biopsy Proteomics for Early Detection of Pancreatic Cancer - Laura F Dagley
• Influenza infection of lung epithelial cells expressing common HLA-I variants to define conserved influenza targets by immunopeptidomics - Ngoc Hong Le
• Using a proteogenomics approach to elucidate the protein isoforms correlating with chemoresistance in ovarian cancer - Atyuha Jain
• Multiplex Olink cytokine profiling of the wound environment in patients with hand infections reveals network of dynamic and highly expressed proinflammatory cytokines - An Qi Ngoh
• Proteomic characterisation of synergistic partners of the antimalarial drug, tafenoquine - Janelle L Hancock
• A data-driven systematic approach to detect protein mistranslation in Saccharomyces Cerevisiae - James R Rosse
• Therapy driven modulation of membrane and soluble immunopeptidome in triple-negative breast cancer: implications for immunotherapy and biomarker discovery - Kirti Pandey
• Technical nuances of plasma proteomic workflows in clinical and preclinical contexts  - Samantha Emery-Corbin
• Understanding the role of peptides in direct CD8+ T cell allorecognition - Hayley Tucker
• Secretome-Driven Modulation of CD8⁺ T Cell Function in the Pancreatic Tumour Microenvironment - Ragini Bhalla
• Copper intrauterine device (IUD) use associates with metaproteomic signatures of genital inflammation, altered epithelial barrier function, and microbial dysbiosis in South African women   - Nina Radzey
• Proteomic Signatures of Noise Damage: A Comparative Study in Rat Inner Ear and Systemic Fluids - Motahare Khorrami
• Constructing region-specific nuclear map of the heart - Seyed Sadegh Eslami
• Spatial proteomics to study immune cells driving inclusion body myositis - Kael Schoffer
• Native glycomics enables true translation of observed glycans to intact glycopeptide detection - Chris Ashwood
• p53 Aggregation: Its Mechanics and Potential Contribution to the Development of Alzheimer’s Disease - David Lynch
• Hunting HERVs: Methods to map endogenous retrovirus expression in neurodegenerative disease - Dezerae Cox
• Atmospheric pressure ionization high-resolution MS histochemistry of FFPE biobanked tissue for the analysis of endogenous (neuro)peptides (as well as metabolites) aligned with today's pathology practice - Peter DEM Verhaert

Decoding Disease: From Single Cells to Immune Targets

Featuring Dr. Mark Larance and A/Prof. Pouya Faridi

Dr. Mark Larance will share how high-resolution MS and single-cell proteomics are enabling deeper insights into disease mechanisms and cellular signalling, bridging discovery research with real clinical impact. A/Prof. Pouya Faridi will present advances in clinical immunopeptidomics enabling high-depth antigen profiling and ultra-sensitive targeted assays that support precision immunotherapy development and real-time clinical decision-making.

• Presentation on statistical and computational analysis of mass spectrometry data, in particular your MSstats pipelines, which are extensively used in our community. - Olga Vitek
• RDMS.app – An online platform for the interrogation and visualisation of rare disease proteomics data. - Nikeisha J Caruana
• Visual Analytics of Immunopeptidomics and Viral Surveillance - Mitchell Jenzen
• MassSpectrum Analyzer: An interactive platform for searching parameter refinement and modification focused re-scoring - Kristian I Karlic